I-Mab is a biotech, founded in Shanghai and now based in Maryland, whose Claudin 18.2 and 4-1BB bispecific givastomig and CD73 antibody uliledlimab are in trials for stomach and lung cancer.
I-Mab develops immuno-oncology biologics and moved its headquarters to Rockville, Maryland after separating from its Chinese operations in 2024. Givastomig (TJ-CD4B), a Claudin 18.2 and 4-1BB bispecific, is in phase 1b/2 trials with nivolumab and chemotherapy in first-line gastric cancer. Uliledlimab (TJ004309) is a differentiated CD73 antibody studied with toripalimab in non-small cell lung cancer. The company also developed lemzoparlimab, a CD47 antibody once licensed to AbbVie.
Uliledlimab is an experimental investigational agent whose form is not stated in the registry from TJ Biopharma in phase 3 trials for non-small-cell lung cancer, with its target not yet stated publicly.