Faron Pharmaceuticals is a Finnish biotech whose antibody bexmarilimab re-programmes immunosuppressive macrophages, with early activity in myelodysplastic syndromes and leukaemia.
Faron Pharmaceuticals, based in Turku and listed in London and Helsinki, develops immunotherapies that act on the myeloid arm of the immune system. Its lead candidate, bexmarilimab (FP-1305), binds Clever-1 on tumour-associated macrophages and converts them from an immunosuppressive to an immune-activating state. The BEXMAB study combines it with azacitidine in myelodysplastic syndromes and acute myeloid leukaemia; earlier MATINS trials tested it in solid tumours.
Bexmarilimab is a monoclonal antibody from Faron Pharmaceuticals Ltd, in registered phase 2 trials for acute myeloid leukaemia, chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, myelodysplastic syndromes / neoplasms.