Corvus Pharmaceuticals is a Californian biotech whose oral ITK inhibitor soquelitinib rebalances T cells, with a registrational trial in relapsed T-cell lymphoma and studies in atopic dermatitis.
Corvus Pharmaceuticals develops soquelitinib (CPI-818), a selective covalent inhibitor of interleukin-2-inducible T-cell kinase (ITK) that blocks malignant T cells and steers helper T cells towards a Th1 profile. It is in a registrational phase 3 trial in relapsed peripheral T-cell lymphoma and in phase 1 trials in atopic dermatitis. The company also developed the adenosine A2A antagonist ciforadenant and the CD73 antibody mupadolimab.
Soquelitinib is an experimental small-molecule drug from Corvus Pharmaceuticals in phase 3 trials for peripheral T-cell lymphomas, with its target not yet stated publicly.