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Cancers
Pancreatic neuroendocrine tumours
What changed

Pancreatic neuroendocrine tumours

What changed: Pancreatic neuroendocrine tumours

Cancer page →

Every dated change on the records linked to Pancreatic neuroendocrine tumours, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

Overview Types and stages Symptoms and diagnosis Treatment Trials and papers Biology and targets Countries and centres Decisions and support Pipeline and open problems Data

Approval4Regulatory2Trial result5Milestone10This record1On Edge

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September 2026 · 1

2026-09-17This recordPancreatic neuroendocrine tumours
Facts on this page last checked
When this page itself was last checked or edited.

2025 · 3

2025ApprovalCabozantinib
Cabozantinib approved in US
Advanced pancreatic and extra-pancreatic neuroendocrine tumours after prior therapy (CABINET)
2025Trial resultCOMPETE
COMPETE reported
PFS 23.
2025MilestoneCabozantinib
Cabozantinib approved; COMPETE published
A milestone in how this cancer is treated.

2024 · 2

2024Trial resultCABINET (Alliance A021602)
CABINET (Alliance A021602) reported
PFS HR 0.
2024MilestoneStudy to Evaluate the Efficacy and Safety of Lutathera in Patients With Grade 2 and Grade 3 Advanced GEP-NET
NETTER-2: first-line lutetium-177 dotatate in grade 2 to 3 disease; CABINET pancreatic cohort published
A milestone in how this cancer is treated.

2023 · 1

2023MilestoneCapecitabine + temozolomide (CAPTEM)
E2211 final analysis: CAPTEM beats temozolomide alone
A milestone in how this cancer is treated.

August 2021 · 1

2021-08-13RegulatoryBelzutifan
Belzutifan: approval (US)
VHL disease-associated RCC, CNS haemangioblastoma, pNET: first HIF-2α inhibitor

2021 · 2

2021ApprovalBelzutifan
Belzutifan approved in US
VHL-associated RCC, CNS haemangioblastoma, pNET
2021MilestoneBelzutifan
Belzutifan approved for VHL-associated pancreatic NET
A milestone in how this cancer is treated.

January 2018 · 1

2018-01-26RegulatoryLutetium-177 dotatate
Lutetium-177 dotatate: approval (US)
SSTR+ gastroenteropancreatic NETs (NETTER-1)

2018 · 1

2018MilestoneLutetium-177 dotatate
Lutathera approved for gastroenteropancreatic tumours
A milestone in how this cancer is treated.

2017 · 1

2017Trial resultNETTER-1
NETTER-1 reported
PFS at 20 months 65.

2014 · 2

2014Trial resultCLARINET
CLARINET reported
PFS HR 0.
2014MilestoneCLARINET
CLARINET: lanreotide approved as antiproliferative therapy
A milestone in how this cancer is treated.

2011 · 4

2011ApprovalEverolimus
Everolimus approved in US
Progressive pancreatic NETs
2011ApprovalSunitinib
Sunitinib approved in US
Progressive pancreatic NETs
2011Trial resultRADIANT-3 and RADIANT-4
RADIANT-3 and RADIANT-4 reported
PFS HR 0.
2011MilestoneRADIANT-3 and RADIANT-4
RADIANT-3 and the sunitinib phase 3 published; everolimus and sunitinib approved; MEN1, DAXX and ATRX mutations mapped by exome sequencing
A milestone in how this cancer is treated.

1982 · 1

1982MilestoneStreptozocin
Streptozocin approved for metastatic islet cell carcinoma
A milestone in how this cancer is treated.

1955 · 1

1955MilestonePancreatic neuroendocrine tumours
Zollinger and Ellison describe the gastrinoma syndrome
A milestone in how this cancer is treated.

1927 · 1

1927MilestonePancreatic neuroendocrine tumours
Wilder describes hyperinsulinism from an islet cell tumour; first successful insulinoma resection follows in 1929
A milestone in how this cancer is treated.