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Every dated change on the records linked to Multisystem Langerhans cell histiocytosis (with or without risk-organ involvement), newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.
12 vs 6 months of vinblastine-prednisone: 5-year reactivation 37% vs 54% in risk-organ-negative disease; methotrexate added no benefit.
A milestone in how this cancer is treated.