What changed: HIV-associated (AIDS-related) lymphomas

When this page itself was last checked or edited.

Case series and the AMC-sponsored study show safety; trial eligibility broadened.

Kaposi sarcoma (AIDS-related after ART failure; HIV-negative)

Outcomes comparable to HIV-negative controls.

One-year overall survival 87.

R-CHOP or dose-adjusted EPOCH-R at full dose with concurrent antiretroviral therapy (avoiding boosted protease inhibitors or cobicistat where possible), G-CSF support and opportunistic-infection prophylaxis; CNS prophylaxis by risk. (NCCN Category 2A)

Sparano and colleagues (Blood 2010) establish concurrent R-EPOCH.

AMC 010 shows excess infection deaths with rituximab at very low CD4; later analyses restrict the risk to CD4 under 50.

Incidence of AIDS-related NHL falls sharply; survival after lymphoma improves as immune function is preserved.

EBV in CNS lymphoma; HHV-8 (KSHV) identified in 1994 and linked to primary effusion lymphoma in 1995.

Aggressive B-cell lymphoma in young men with AIDS reported; added to the CDC case definition in 1985.