What changed: Ampullary cancer (ampulla of Vater)

When this page itself was last checked or edited.

3-year overall survival 77.

Subtype-directed treatment recommendations formalised.

Six months of chemotherapy chosen by subtype: oxaliplatin-fluoropyrimidine (FOLFOX or CAPOX) for intestinal-type; gemcitabine-based or modified FOLFIRINOX for pancreatobiliary-type; evidence is from ESPAC-3 periampullary and retrospective series. (NCCN Category 2A)

Adjuvant chemotherapy after resection of periampullary cancer; survival benefit in adjusted analysis.

Median overall survival 23.

Kimura and colleagues link histological type to prognosis.

Allen Whipple reports the operation that became the standard for periampullary cancer.

First successful local resection of a periampullary tumour.