Loading
Muscle-invasive bladder cancer, cisplatin-eligible, before cystectomy
Also called ddMVAC, accelerated MVAC, MVAC.
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Methotrexate Antifolate (DHFR inhibitor) | 30 mg/m² | IV | D1 | |
Vinblastine Vinca alkaloid (microtubule inhibitor) | 3 mg/m² | IV | D2 | |
Doxorubicin Cytotoxic chemotherapy (anthracycline) | 30 mg/m² | IV | D2 | |
Cisplatin Cytotoxic chemotherapy (platinum) | 70 mg/m² | IV | D2 |
NCCN Bladder Cancer; Sternberg (EORTC 30924), JCO 2001
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.