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ZRSR2 (U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Skin cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"ZRSR2" OR ABSTRACT:"ZRSR2" OR TITLE:"zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" OR ABSTRACT:"zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" OR TITLE:"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2" OR ABSTRACT:"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2" OR TITLE:"U2AF1-RS2" OR ABSTRACT:"U2AF1-RS2" OR TITLE:"ZC3H22" OR ABSTRACT:"ZC3H22" OR TITLE:"U2AF1L2" OR ABSTRACT:"U2AF1L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZRSR2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/zrsr2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zrsr2.json. Licence CC BY-NC 4.0.