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ZBTB16 (Zinc finger and BTB domain-containing protein 16) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Oesophageal cancer, Skin cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Location: Nucleus; Nucleus, nuclear body (UniProt). Locus 11q23.2 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 1-9% | Deletion or truncating mutation | cBioPortal ZBTB16 deep deletion: 43 of 1,013, 4.2%, in prad_p1000; 17 of 489, 3.5%, in prad_tcga_pan_can_atlas_2018; 13 of 444, 2.9%, in prad_su2c_2019; 8 of 150, 5.3%, in prad_su2c_2015. ZFHX3 mutation: 142 of 2,260, 6.3%, in prostate_msk_2024; 22 of 444, 5.0%, in prad_su2c_2019, with deep deletion 29 of 489, 5.9%, in prad_tcga_pan_can_atlas_2018. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ZBTB16" OR ABSTRACT:"ZBTB16" OR TITLE:"zinc finger and BTB domain containing 16" OR ABSTRACT:"zinc finger and BTB domain containing 16" OR TITLE:"Zinc finger and BTB domain-containing protein 16" OR ABSTRACT:"Zinc finger and BTB domain-containing protein 16" OR TITLE:"ZNF145" OR ABSTRACT:"ZNF145") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZBTB16, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/zbtb16.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zbtb16.json. Licence CC BY-NC 4.0.