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YAP1 (Transcriptional coactivator YAP1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Oesophageal cancer and Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signalling pathway, crucial for organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The Hippo signalling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes. The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT). Location: Cytoplasm; Nucleus; Cell junction, tight junction; Cell membrane (UniProt). Locus 11q22.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"YAP1" OR ABSTRACT:"YAP1" OR TITLE:"Yes1 associated transcriptional regulator" OR ABSTRACT:"Yes1 associated transcriptional regulator" OR TITLE:"Transcriptional coactivator YAP1" OR ABSTRACT:"Transcriptional coactivator YAP1" OR TITLE:"YAP65" OR ABSTRACT:"YAP65" OR TITLE:"YAP-1" OR ABSTRACT:"YAP-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about YAP1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/yap1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/yap1.json. Licence CC BY-NC 4.0.