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The export pump that carries tumour suppressor proteins such as p53 out of the nucleus, where they cannot act. Selinexor blocks it so those brakes stay in the nucleus and cancer cells die. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Karyopherin that exports nuclear export signal-bearing proteins and some RNAs; inhibited covalently by selinexor at Cys528.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Hodgkin lymphoma | 26% | XPO1 mutation (mostly E571K), sequencing, 5 of 19 cases | Small series; the same study found XPO1 mutations in 24% of primary mediastinal B-cell lymphoma (28 of 117) and in under 2% of other diffuse large B-cell lymphoma | doi.org |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Exportin-1" OR ABSTRACT:"Exportin-1" OR TITLE:"XPO1" OR ABSTRACT:"XPO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Exportin-1 (XPO1), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/xpo1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/xpo1.json. Licence CC BY-NC 4.0.