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USP6 (Ubiquitin carboxyl-terminal hydrolase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Breast cancer, Hepatocellular carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyses its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localisation of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A. Location: Cell membrane; Cytoplasm; Endosome (UniProt). Locus 17p13.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"USP6" OR ABSTRACT:"USP6" OR TITLE:"ubiquitin specific peptidase 6" OR ABSTRACT:"ubiquitin specific peptidase 6" OR TITLE:"Ubiquitin carboxyl-terminal hydrolase 6" OR ABSTRACT:"Ubiquitin carboxyl-terminal hydrolase 6" OR TITLE:"Tre-2" OR ABSTRACT:"Tre-2" OR TITLE:"TRE17" OR ABSTRACT:"TRE17" OR TITLE:"Tre2" OR ABSTRACT:"Tre2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about USP6, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/usp6.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/usp6.json. Licence CC BY-NC 4.0.