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TCF7L2 (Transcription factor 7-like 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Breast cancer, Prostate cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Participates in the Wnt signalling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Location: Nucleus, PML body; Nucleus (UniProt). Locus 10q25.2-q25.3 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Colorectal cancer | 7-15% | Mutation or VTI1A-TCF7L2 fusion | cBioPortal: 1,088 of 7,237, 15.0%, in crc_msk_2026; 124 of 1,134, 10.9%, in crc_msk_2017; 58 of 534, 10.9%, in coadread_tcga_pan_can_atlas_2018; 44 of 619, 7.1%, in coadread_dfci_2016. Structural variants involving TCF7L2 appear in 4 of 594 TCGA samples (VTI1A-TCF7L2 in 3) and 12 of 7,237 in crc_msk_2026. Recurrent TCF7L2 mutations were among the new findings of the Genentech exome and transcriptome series, and the TCGA analysis reported a NAV2-TCF7L1 fusion (Seshagiri 2012, Cancer Genome Atlas Network 2012). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"TCF7L2" OR ABSTRACT:"TCF7L2" OR TITLE:"transcription factor 7 like 2" OR ABSTRACT:"transcription factor 7 like 2" OR TITLE:"Transcription factor 7-like 2" OR ABSTRACT:"Transcription factor 7-like 2" OR TITLE:"TCF-4" OR ABSTRACT:"TCF-4" OR TITLE:"TCF4" OR ABSTRACT:"TCF4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCF7L2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tcf7l2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tcf7l2.json. Licence CC BY-NC 4.0.