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SRGAP1 (SLIT-ROBO Rho GTPase-activating protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signalling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Locus 12q14.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SRGAP1" OR ABSTRACT:"SRGAP1" OR TITLE:"SLIT-ROBO Rho GTPase activating protein 1" OR ABSTRACT:"SLIT-ROBO Rho GTPase activating protein 1" OR TITLE:"SLIT-ROBO Rho GTPase-activating protein 1" OR ABSTRACT:"SLIT-ROBO Rho GTPase-activating protein 1" OR TITLE:"KIAA1304" OR ABSTRACT:"KIAA1304" OR TITLE:"ARHGAP13" OR ABSTRACT:"ARHGAP13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRGAP1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/srgap1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/srgap1.json. Licence CC BY-NC 4.0.