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SOX9 (Transcription factor SOX-9) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Location: Nucleus (UniProt). Locus 17q24.3 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Colorectal cancer | 10-12% | Inactivating mutation | cBioPortal: 869 of 7,237, 12.0%, in crc_msk_2026; 64 of 534, 12.0%, in coadread_tcga_pan_can_atlas_2018; 62 of 619, 10.0%, in coadread_dfci_2016; 154 of 1,516, 10.2%, in crc_eo_2020; 107 of 1,134, 9.4%, in crc_msk_2017. Named as a new significantly mutated gene by the TCGA analysis (Cancer Genome Atlas Network 2012). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
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Query for this target: (TITLE:"SOX9" OR ABSTRACT:"SOX9" OR TITLE:"SRY-box transcription factor 9" OR ABSTRACT:"SRY-box transcription factor 9" OR TITLE:"Transcription factor SOX-9" OR ABSTRACT:"Transcription factor SOX-9" OR TITLE:"SRA1" OR ABSTRACT:"SRA1" OR TITLE:"CMD1" OR ABSTRACT:"CMD1" OR TITLE:"CMPD1" OR ABSTRACT:"CMPD1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SOX9, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/sox9.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sox9.json. Licence CC BY-NC 4.0.