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SOX2 (Transcription factor SOX-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer and Lung cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. Location: Nucleus speckle; Cytoplasm; Nucleus (UniProt). Locus 3q26.33 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Non-small-cell lung cancer | 29-43% | High-level amplification of the squamous lineage programme | cBioPortal high-level amplification: SOX2 194 of 487, 39.8%, and TP63 154 of 487, 31.6%, in lusc_tcga_pan_can_atlas_2018; SOX2 76 of 178, 42.7%, and TP63 51 of 178, 28.7%, in lusc_tcga_pub; SOX2 220 of 1,144, 19.2%, and TP63 176, 15.4%, in the combined nsclc_tcga_broad_2016. In adenocarcinoma the same genes are amplified in 10 of 511 (2.0%) and 10 of 511 (2.0%). The founding paper counted squamous differentiation genes altered in 44% of tumours (Cancer Genome Atlas Research Network 2012). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"SOX2" OR ABSTRACT:"SOX2" OR TITLE:"SRY-box transcription factor 2" OR ABSTRACT:"SRY-box transcription factor 2" OR TITLE:"Transcription factor SOX-2" OR ABSTRACT:"Transcription factor SOX-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SOX2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/sox2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sox2.json. Licence CC BY-NC 4.0.