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SAMHD1 (Deoxynucleoside triphosphate triphosphohydrolase SAMHD1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx. In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks. Location: Nucleus; Chromosome (UniProt). Locus 20q11.23 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"SAMHD1" OR ABSTRACT:"SAMHD1" OR TITLE:"SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1" OR ABSTRACT:"SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1" OR TITLE:"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1" OR ABSTRACT:"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1" OR TITLE:"SBBI88" OR ABSTRACT:"SBBI88" OR TITLE:"Mg11" OR ABSTRACT:"Mg11" OR TITLE:"HDDC1" OR ABSTRACT:"HDDC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SAMHD1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/samhd1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/samhd1.json. Licence CC BY-NC 4.0.