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RGS17 (Regulator of G protein signalling 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Regulates G protein-coupled receptor signalling cascades, including signalling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signalling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins. Location: Membrane; Synapse, synaptosome; Nucleus; Cytoplasm (UniProt). Locus 6q25.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RGS17" OR ABSTRACT:"RGS17" OR TITLE:"regulator of G protein signaling 17" OR ABSTRACT:"regulator of G protein signaling 17" OR TITLE:"Regulator of G protein signaling 17" OR ABSTRACT:"Regulator of G protein signaling 17" OR TITLE:"RGSZ2" OR ABSTRACT:"RGSZ2" OR TITLE:"RGS-17" OR ABSTRACT:"RGS-17") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RGS17, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rgs17.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rgs17.json. Licence CC BY-NC 4.0.