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RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. Location: Nucleus, nucleolus (UniProt). Locus Xp11.3 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Non-small-cell lung cancer | 7-11% | Inactivating mutation (splicing regulator) | cBioPortal: 294 of 2,653, 11.1%, in luad_mskcc_2023_met_organotropism; 78 of 915, 8.5%, in lung_msk_2017; 38 of 566, 6.7%, in luad_tcga_pan_can_atlas_2018; 19 of 230, 8.3%, in luad_tcga_pub; 22 of 302, 7.3%, in luad_oncosg_2020; 17 of 232, 7.3%, in lung_nci_2022; 6 of 484, 1.2%, in lusc_tcga_pan_can_atlas_2018. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RBM10" OR ABSTRACT:"RBM10" OR TITLE:"RNA binding motif protein 10" OR ABSTRACT:"RNA binding motif protein 10" OR TITLE:"Ribosome biogenesis inhibitor MINAS-60" OR ABSTRACT:"Ribosome biogenesis inhibitor MINAS-60" OR TITLE:"DXS8237E" OR ABSTRACT:"DXS8237E" OR TITLE:"KIAA0122" OR ABSTRACT:"KIAA0122" OR TITLE:"GPATC9" OR ABSTRACT:"GPATC9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBM10, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rbm10.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rbm10.json. Licence CC BY-NC 4.0.