Loading
PREX2 is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signalling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. Locus 8q13.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PREX2" OR ABSTRACT:"PREX2" OR TITLE:"phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2" OR ABSTRACT:"phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2" OR TITLE:"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein" OR ABSTRACT:"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein" OR TITLE:"DEP.2" OR ABSTRACT:"DEP.2" OR TITLE:"FLJ12987" OR ABSTRACT:"FLJ12987" OR TITLE:"P-REX2" OR ABSTRACT:"P-REX2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PREX2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/prex2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/prex2.json. Licence CC BY-NC 4.0.