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PPP2R1A is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localisation of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signalling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. Location: Cytoplasm; Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus 19q13.41 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PPP2R1A" OR ABSTRACT:"PPP2R1A" OR TITLE:"protein phosphatase 2 scaffold subunit Aalpha" OR ABSTRACT:"protein phosphatase 2 scaffold subunit Aalpha" OR TITLE:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform" OR TITLE:"PR65A" OR ABSTRACT:"PR65A" OR TITLE:"PP2A-Aalpha" OR ABSTRACT:"PP2A-Aalpha" OR TITLE:"PP2AA" OR ABSTRACT:"PP2AA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R1A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ppp2r1a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ppp2r1a.json. Licence CC BY-NC 4.0.