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PPM1D (Protein phosphatase 1D) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Ovarian cancer, Myeloproliferative neoplasms and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. Location: Nucleus; Cytoplasm, cytosol (UniProt). Locus 17q23.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PPM1D" OR ABSTRACT:"PPM1D" OR TITLE:"protein phosphatase, Mg2+/Mn2+ dependent 1D" OR ABSTRACT:"protein phosphatase, Mg2+/Mn2+ dependent 1D" OR TITLE:"Protein phosphatase 1D" OR ABSTRACT:"Protein phosphatase 1D" OR TITLE:"Wip1" OR ABSTRACT:"Wip1" OR TITLE:"PP2C-DELTA" OR ABSTRACT:"PP2C-DELTA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPM1D, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ppm1d.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ppm1d.json. Licence CC BY-NC 4.0.