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POLD3 (DNA polymerase delta subunit 3) is a gene. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Lung cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilises the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterised by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Location: Cytoplasm; Nucleus (UniProt). Locus 11q13.4 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"POLD3" OR ABSTRACT:"POLD3" OR TITLE:"DNA polymerase delta 3, accessory subunit" OR ABSTRACT:"DNA polymerase delta 3, accessory subunit" OR TITLE:"DNA polymerase delta subunit 3" OR ABSTRACT:"DNA polymerase delta subunit 3" OR TITLE:"P66" OR ABSTRACT:"P66" OR TITLE:"KIAA0039" OR ABSTRACT:"KIAA0039" OR TITLE:"P68" OR ABSTRACT:"P68") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POLD3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/pold3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pold3.json. Licence CC BY-NC 4.0.