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PNPLA3 (1-acylglycerol-3-phosphate O-acyltransferase PNPLA3) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Hepatocellular carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Specifically catalyses coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Location: Membrane; Lipid droplet (UniProt). Locus 22q13.31 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PNPLA3" OR ABSTRACT:"PNPLA3" OR TITLE:"patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase" OR ABSTRACT:"patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase" OR TITLE:"1-acylglycerol-3-phosphate O-acyltransferase PNPLA3" OR ABSTRACT:"1-acylglycerol-3-phosphate O-acyltransferase PNPLA3" OR TITLE:"dJ796I17.1" OR ABSTRACT:"dJ796I17.1" OR TITLE:"FLJ22012" OR ABSTRACT:"FLJ22012" OR TITLE:"adiponutrin" OR ABSTRACT:"adiponutrin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PNPLA3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/pnpla3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pnpla3.json. Licence CC BY-NC 4.0.