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PLCG2 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Chronic lymphocytic leukaemia. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 1 resistance route in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signalling. Location: Membrane raft (UniProt). Locus 16q24.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
R665W and L845F make B-cell receptor signalling autonomous below the kinase, so blocking BTK above them achieves nothing.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PLCG2" OR ABSTRACT:"PLCG2" OR TITLE:"phospholipase C gamma 2" OR ABSTRACT:"phospholipase C gamma 2" OR TITLE:"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2" OR ABSTRACT:"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLCG2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/plcg2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/plcg2.json. Licence CC BY-NC 4.0.