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The progesterone receptor is the hormone receptor that, alongside the oestrogen receptor, marks breast cancers likely to respond to hormone therapy, and it is the target of the progestins megestrol and medroxyprogesterone used in endometrial and breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
PGR encodes two isoforms, PR-A and PR-B, from alternative promoters; the receptor binds progesterone, dimerises and regulates transcription at progesterone response elements, and it cross-talks with the oestrogen receptor at shared chromatin sites. In breast cancer PR expression is a marker of ER activity and of luminal A biology; loss of PR in an ER-positive tumour predicts a poorer response to endocrine therapy. In the endometrium progesterone opposes oestrogen-driven proliferation, which is why unopposed oestrogen causes endometrial cancer and progestins treat it.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| HR-positive / HER2-negative breast cancer | about 65-70% | Progesterone receptor-positive by immunohistochemistry | cancer.org |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"Progesterone receptor" OR ABSTRACT:"Progesterone receptor" OR TITLE:"PGR" OR ABSTRACT:"PGR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Progesterone receptor (PGR), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/pgr.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pgr.json. Licence CC BY-NC 4.0.