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PDCD1LG2 (Programmed cell death 1 ligand 2) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a biomarker and an antigen, and an approved or late-stage drug is recorded against it. Tied to Head and neck squamous cell carcinoma, Thyroid cancer, Breast cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Plays a critical role in induction and maintenance of immune tolerance to self. Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production. Location: Secreted; Endomembrane system; Cell membrane (UniProt). Locus 9p24.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PDCD1LG2" OR ABSTRACT:"PDCD1LG2" OR TITLE:"programmed cell death 1 ligand 2" OR ABSTRACT:"programmed cell death 1 ligand 2" OR TITLE:"Programmed cell death 1 ligand 2" OR ABSTRACT:"Programmed cell death 1 ligand 2" OR TITLE:"PD-L2" OR ABSTRACT:"PD-L2" OR TITLE:"Btdc" OR ABSTRACT:"Btdc" OR TITLE:"PDL2" OR ABSTRACT:"PDL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDCD1LG2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/pdcd1lg2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pdcd1lg2.json. Licence CC BY-NC 4.0.