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NR5A2 (Nuclear receptor subfamily 5 group A member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis. Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation. The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro. Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin. Plays a central role during preimplantation stages of embryonic development. Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes. Location: Nucleus; Chromosome (UniProt). Locus 1q32.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"NR5A2" OR ABSTRACT:"NR5A2" OR TITLE:"nuclear receptor subfamily 5 group A member 2" OR ABSTRACT:"nuclear receptor subfamily 5 group A member 2" OR TITLE:"Nuclear receptor subfamily 5 group A member 2" OR ABSTRACT:"Nuclear receptor subfamily 5 group A member 2" OR TITLE:"FTZ-F1beta" OR ABSTRACT:"FTZ-F1beta" OR TITLE:"hB1F" OR ABSTRACT:"hB1F" OR TITLE:"LRH-1" OR ABSTRACT:"LRH-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NR5A2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/nr5a2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nr5a2.json. Licence CC BY-NC 4.0.