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NKX2-1 (Homeobox protein Nkx-2.1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thyroid cancer, Lung cancer, Skin cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. Location: Nucleus (UniProt). Locus 14q13.3 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Non-small-cell lung cancer | 8-14% | High-level amplification (lineage survival gene) | cBioPortal high-level amplification: 261 of 2,422, 10.8%, in luad_mskcc_2023_met_organotropism; 75 of 915, 8.2%, in lung_msk_2017; 67 of 511, 13.1%, in luad_tcga_pan_can_atlas_2018; 32 of 230, 13.9%, in luad_tcga_pub; 11 of 302, 3.6%, in luad_oncosg_2020; 13 of 487, 2.7%, in lusc_tcga_pan_can_atlas_2018. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"NKX2-1" OR ABSTRACT:"NKX2-1" OR TITLE:"NK2 homeobox 1" OR ABSTRACT:"NK2 homeobox 1" OR TITLE:"Homeobox protein Nkx-2.1" OR ABSTRACT:"Homeobox protein Nkx-2.1" OR TITLE:"TTF-1" OR ABSTRACT:"TTF-1" OR TITLE:"TTF1" OR ABSTRACT:"TTF1" OR TITLE:"NKX2A" OR ABSTRACT:"NKX2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NKX2-1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/nkx2-1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nkx2-1.json. Licence CC BY-NC 4.0.