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MYH9 (Myosin-9) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Breast cancer, Colorectal cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialised functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganisation, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonised by MYH10. Location: Cytoplasm, cytoskeleton; Cytoplasm, cell cortex; Cytoplasmic vesicle, secretory vesicle, Cortical granule; Cell membrane (UniProt). Locus 22q12.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MYH9" OR ABSTRACT:"MYH9" OR TITLE:"myosin heavy chain 9" OR ABSTRACT:"myosin heavy chain 9" OR TITLE:"Myosin-9" OR ABSTRACT:"Myosin-9" OR TITLE:"NMMHCA" OR ABSTRACT:"NMMHCA" OR TITLE:"NMHC-II-A" OR ABSTRACT:"NMHC-II-A" OR TITLE:"EPSTS" OR ABSTRACT:"EPSTS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYH9, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/myh9.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/myh9.json. Licence CC BY-NC 4.0.