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Ki-67 is a protein present only in cells that are dividing, so the share of tumour cells that stain for it is a direct read of how fast the cancer is growing. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Ki-67 coats the surface of mitotic chromosomes and keeps them from clumping; its level rises through S, G2 and M phase and falls to nothing in quiescent cells, which is why the stained fraction tracks proliferation.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Ki-67" OR ABSTRACT:"Ki-67" OR TITLE:"MKI67" OR ABSTRACT:"MKI67" OR TITLE:"Ki67" OR ABSTRACT:"Ki67" OR TITLE:"MIB-1" OR ABSTRACT:"MIB-1" OR TITLE:"marker of proliferation Ki-67" OR ABSTRACT:"marker of proliferation Ki-67") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Ki-67 (MKI67), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mki67.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mki67.json. Licence CC BY-NC 4.0.