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MGA (MAX gene-associated protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mesothelioma, Prostate cancer, Diffuse large B-cell lymphoma and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerisation with MAX. This heterodimerisation serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. Location: Nucleus (UniProt). Locus 15q15 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"MGA" OR ABSTRACT:"MGA" OR TITLE:"MAX dimerization protein MGA" OR ABSTRACT:"MAX dimerization protein MGA" OR TITLE:"MAX gene-associated protein" OR ABSTRACT:"MAX gene-associated protein" OR TITLE:"KIAA0518" OR ABSTRACT:"KIAA0518" OR TITLE:"MAD5" OR ABSTRACT:"MAD5" OR TITLE:"MXD5" OR ABSTRACT:"MXD5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MGA, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mga.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mga.json. Licence CC BY-NC 4.0.