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MCL1 (Induced myeloid leukaemia cell differentiation protein Mcl-1) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 1 resistance route in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Location: Membrane; Cytoplasm; Mitochondrion; Nucleus, nucleoplasm (UniProt). Locus 1q21.2 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
A cell that needed BCL-2 can be made to need its relatives instead, which is the main reason venetoclax has not repeated its chronic lymphocytic leukaemia result in follicular and large B-cell lymphoma.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MCL1" OR ABSTRACT:"MCL1" OR TITLE:"MCL1 apoptosis regulator, BCL2 family member" OR ABSTRACT:"MCL1 apoptosis regulator, BCL2 family member" OR TITLE:"Induced myeloid leukemia cell differentiation protein Mcl-1" OR ABSTRACT:"Induced myeloid leukemia cell differentiation protein Mcl-1" OR TITLE:"BCL2L3" OR ABSTRACT:"BCL2L3" OR TITLE:"Mcl-1" OR ABSTRACT:"Mcl-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MCL1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mcl1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mcl1.json. Licence CC BY-NC 4.0.