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MC1R (Melanocyte-stimulating hormone receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein. Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signalling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis. Binding to Agouti/ASP precludes alpha-MSH-induced signalling, thereby down-regulating melanogenesis. Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signalling. Location: Cell membrane (UniProt). Locus 16q24.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"MC1R" OR ABSTRACT:"MC1R" OR TITLE:"melanocortin 1 receptor" OR ABSTRACT:"melanocortin 1 receptor" OR TITLE:"Melanocyte-stimulating hormone receptor" OR ABSTRACT:"Melanocyte-stimulating hormone receptor" OR TITLE:"MSH-R" OR ABSTRACT:"MSH-R") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MC1R, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/mc1r.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mc1r.json. Licence CC BY-NC 4.0.