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KDM6A (Lysine-specific demethylase 6A) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Prostate cancer, Pancreatic ductal adenocarcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Location: Nucleus (UniProt). Locus Xp11.3 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Pancreatic ductal adenocarcinoma | 3-4% | Inactivating mutation or structural disruption | cBioPortal: 91 of 2,336, 3.9%, in pdac_msk_2024; 12 of 383, 3.1%, in paad_qcmg_uq_2016; 7 of 179, 3.9%, in paad_tcga_pan_can_atlas_2018; 12 of 395, 3.0%, in pancreas_msk_2024. Named a new candidate driver by structural variation in 100 whole genomes (Waddell 2015); the squamous subtype is enriched for KDM6A mutation (Bailey 2016); KDM6A loss induced squamous-like, metastatic tumours through super-enhancer activation of TP63, MYC and RUNX3 and conferred BET inhibitor sensitivity in mice (Andricovich 2018). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"KDM6A" OR ABSTRACT:"KDM6A" OR TITLE:"lysine demethylase 6A" OR ABSTRACT:"lysine demethylase 6A" OR TITLE:"Lysine-specific demethylase 6A" OR ABSTRACT:"Lysine-specific demethylase 6A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KDM6A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/kdm6a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/kdm6a.json. Licence CC BY-NC 4.0.