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KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon. Associates with KCNE beta subunits that modulates current kinetics. Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current. Also promotes a delayed voltage activated potassium current showing outward rectification characteristic. During beta-adrenergic receptor stimulation, participates in cardiac repolarisation by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current. Location: Cell membrane; Cytoplasmic vesicle membrane; Early endosome; Membrane raft (UniProt). Locus 11p15.5-p15.4 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"KCNQ1" OR ABSTRACT:"KCNQ1" OR TITLE:"potassium voltage-gated channel subfamily Q member 1" OR ABSTRACT:"potassium voltage-gated channel subfamily Q member 1" OR TITLE:"Potassium voltage-gated channel subfamily KQT member 1" OR ABSTRACT:"Potassium voltage-gated channel subfamily KQT member 1" OR TITLE:"Kv7.1" OR ABSTRACT:"Kv7.1" OR TITLE:"KCNA8" OR ABSTRACT:"KCNA8" OR TITLE:"KVLQT1" OR ABSTRACT:"KVLQT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNQ1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/kcnq1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/kcnq1.json. Licence CC BY-NC 4.0.