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HNRNPA2B1 (Heterogeneous nuclear ribonucleoproteins A2/B1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Leukaemia and Non-Hodgkin lymphoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilise the transcripts and minimise tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognising and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Location: Nucleus; Nucleus, nucleoplasm; Cytoplasm; Cytoplasmic granule (UniProt). Locus 7p15.2 (HGNC).
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Query for this target: (TITLE:"HNRNPA2B1" OR ABSTRACT:"HNRNPA2B1" OR TITLE:"heterogeneous nuclear ribonucleoprotein A2/B1" OR ABSTRACT:"heterogeneous nuclear ribonucleoprotein A2/B1" OR TITLE:"Heterogeneous nuclear ribonucleoproteins A2/B1" OR ABSTRACT:"Heterogeneous nuclear ribonucleoproteins A2/B1" OR TITLE:"HNRNPA2" OR ABSTRACT:"HNRNPA2" OR TITLE:"HNRNPB1" OR ABSTRACT:"HNRNPB1" OR TITLE:"HNRPA2B1" OR ABSTRACT:"HNRPA2B1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNRNPA2B1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/hnrnpa2b1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hnrnpa2b1.json. Licence CC BY-NC 4.0.