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HLA-DQA1 (HLA class II histocompatibility antigen, DQ alpha 1 chain) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. Location: Cell membrane; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network membrane; Endosome membrane (UniProt). Locus 6p21.32 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"HLA-DQA1" OR ABSTRACT:"HLA-DQA1" OR TITLE:"major histocompatibility complex, class II, DQ alpha 1" OR ABSTRACT:"major histocompatibility complex, class II, DQ alpha 1" OR TITLE:"HLA class II histocompatibility antigen, DQ alpha 1 chain" OR ABSTRACT:"HLA class II histocompatibility antigen, DQ alpha 1 chain" OR TITLE:"CELIAC1" OR ABSTRACT:"CELIAC1" OR TITLE:"HLA-DQA" OR ABSTRACT:"HLA-DQA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HLA-DQA1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/hla-dqa1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hla-dqa1.json. Licence CC BY-NC 4.0.