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HCAR3 (Hydroxycarboxylic acid receptor 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
G protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. Signals through the inhibitory G(i)/o family of G proteins. Acts as a negative feedback regulator of adipocyte lipolysis, helping to counterbalance prolipolytic signals during physiological or pathological elevations in beta-oxidation. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Location: Cell membrane (UniProt). Locus 12q24.31 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"HCAR3" OR ABSTRACT:"HCAR3" OR TITLE:"hydroxycarboxylic acid receptor 3" OR ABSTRACT:"hydroxycarboxylic acid receptor 3" OR TITLE:"Hydroxycarboxylic acid receptor 3" OR ABSTRACT:"Hydroxycarboxylic acid receptor 3" OR TITLE:"HCA3" OR ABSTRACT:"HCA3" OR TITLE:"HM74" OR ABSTRACT:"HM74" OR TITLE:"GPR109B" OR ABSTRACT:"GPR109B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HCAR3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/hcar3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hcar3.json. Licence CC BY-NC 4.0.