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H3.3 is one of the histone proteins DNA wraps around; a single change at position 27 (K27M) locks brain-stem and midline gliomas in an immature state and defines the diagnosis. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
K27M inhibits the PRC2 methyltransferase EZH2, collapsing global H3K27 trimethylation and blocking differentiation; the mutant histone is detected by a mutation-specific antibody or by sequencing.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Histone H3.3" OR ABSTRACT:"Histone H3.3" OR TITLE:"H3-3A" OR ABSTRACT:"H3-3A" OR TITLE:"H3F3A" OR ABSTRACT:"H3F3A" OR TITLE:"H3.3 histone A" OR ABSTRACT:"H3.3 histone A" OR TITLE:"histone H3.3" OR ABSTRACT:"histone H3.3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Histone H3.3 (H3-3A), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/h3-3a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/h3-3a.json. Licence CC BY-NC 4.0.