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GNAS (Neuroendocrine secretory protein 55) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Pancreatic ductal adenocarcinoma, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
UniProt has no function text for O95467; HGNC names it "GNAS complex locus". Location: Cytoplasmic vesicle, secretory vesicle; Secreted (UniProt). Locus 20q13.32 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Pancreatic ductal adenocarcinoma | 2-4% | R201 hotspot mutation (IPMN-derived tumours) | cBioPortal: 76 of 2,336, 3.3% (R201H 39, R201C 21, R201S 3), in pdac_msk_2024; 7 of 179, 3.9% (R201C 4, R201H 2), in paad_tcga_pan_can_atlas_2018; 10 of 383, 2.6%, in paad_qcmg_uq_2016; 9 of 395, 2.3%, in pancreas_msk_2024; 5 of 109 in paad_utsw_2015; GNAS was a recurrent gene in the TCGA analysis and KRAS wild-type tumours carried GNAS among their drivers (Cancer Genome Atlas 2017). GNAS mutations in 66% of 132 IPMNs, KRAS or GNAS in 96%, carried into the invasive cancer in 7 of 8 IPMN-associated carcinomas and absent from other cysts and from non-IPMN cancers (Wu 2011); 27 of 456 QCMG tumours were IPMN with invasion (cBioPortal histology). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"GNAS" OR ABSTRACT:"GNAS" OR TITLE:"GNAS complex locus" OR ABSTRACT:"GNAS complex locus" OR TITLE:"Neuroendocrine secretory protein 55" OR ABSTRACT:"Neuroendocrine secretory protein 55" OR TITLE:"NESP55" OR ABSTRACT:"NESP55" OR TITLE:"GNASXL" OR ABSTRACT:"GNASXL" OR TITLE:"SCG6" OR ABSTRACT:"SCG6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GNAS, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/gnas.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/gnas.json. Licence CC BY-NC 4.0.