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The receptor that steroid hormones switch on inside cells. In lymphoid cancers, dexamethasone and prednisone acting through it kill malignant lymphocytes directly, which is why steroids sit inside leukaemia, lymphoma and myeloma regimens as well as easing nausea and swelling. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Ligand-activated nuclear receptor; in lymphoid cells its transcriptional programme induces apoptosis, the basis of steroid use in leukaemia, lymphoma and myeloma.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Acute lymphoblastic leukaemia | nearly all% | Glucocorticoid receptor expressed in lymphoblasts; prednisone response is a prognostic marker | cancer.gov |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"Glucocorticoid receptor" OR ABSTRACT:"Glucocorticoid receptor" OR TITLE:"NR3C1" OR ABSTRACT:"NR3C1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Glucocorticoid receptor (NR3C1), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/glucocorticoid-receptor.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/glucocorticoid-receptor.json. Licence CC BY-NC 4.0.