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ETV1 (ETS translocation variant 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Breast cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH). Location: Nucleus (UniProt). Locus 7p21.2 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 1-14% | Fusion of a non-ERG ETS transcription factor, usually to TMPRSS2 or SLC45A3 | cBioPortal, samples: in prad_tcga_pub, ETV1 29 of 333 (8.7%), ETV4 16 (4.8%) and FLI1 4 (1.2%), matching the TCGA paper's 8%, 4% and 1%; in prad_tcga_pan_can_atlas_2018, ETV1 11, ETV4 12 and ETV5 2 of 494; in prad_p1000, ETV1 45, ETV4 23 and FLI1 5 of 1,013; in prad_su2c_2019, ETV1 22, ETV4 12, ETV5 3 and FLI1 1 of 444. Counting any ETS fusion together: 224 of 494, 45.3%, in prad_tcga_pan_can_atlas_2018; 378 of 1,013, 37.3%, in prad_p1000; 172 of 444, 38.7%, in prad_su2c_2019; 564 of 2,260, 25.0%, in prostate_msk_2024. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ETV1" OR ABSTRACT:"ETV1" OR TITLE:"ETS variant transcription factor 1" OR ABSTRACT:"ETS variant transcription factor 1" OR TITLE:"ETS translocation variant 1" OR ABSTRACT:"ETS translocation variant 1" OR TITLE:"ER81" OR ABSTRACT:"ER81") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETV1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/etv1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/etv1.json. Licence CC BY-NC 4.0.