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ERG (Transcriptional regulator ERG) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Prostate cancer, Non-Hodgkin lymphoma and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Location: Nucleus; Cytoplasm (UniProt). Locus 21q22.2 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Prostate cancer | 25-46% | Gene fusion putting ERG under an androgen-responsive promoter | cBioPortal structural variants, samples with an ERG rearrangement: 152 of 333, 45.6%, in prad_tcga_pub, which reproduces the 46% the TCGA paper reports; 203 of 494, 41.1%, in prad_tcga_pan_can_atlas_2018; 305 of 1,013, 30.1%, in prad_p1000; 104 of 424, 24.5%, in prad_mcspc_mskcc_2020; 127 of 504, 25.2%, in prad_mskcc_2017; 544 of 2,260, 24.1%, in prostate_msk_2024; 528 of 2,069, 25.5%, in prad_msk_stopsack_2021; 134 of 444, 30.2%, in prad_su2c_2019; 62 of 150, 41.3%, in prad_su2c_2015. TMPRSS2 is the partner in almost all of them: 194 of the 203 TCGA PanCancer events, 305 of 305 in prad_p1000 and 128 of 134 in prad_su2c_2019, with SLC45A3 and NDRG1 supplying the rest. | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ERG" OR ABSTRACT:"ERG" OR TITLE:"ETS transcription factor ERG" OR ABSTRACT:"ETS transcription factor ERG" OR TITLE:"Transcriptional regulator ERG" OR ABSTRACT:"Transcriptional regulator ERG" OR TITLE:"erg-3" OR ABSTRACT:"erg-3" OR TITLE:"p55" OR ABSTRACT:"p55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERG, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/erg.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/erg.json. Licence CC BY-NC 4.0.