Loading
The receptor that tells the marrow to make red blood cells. Epoetin stimulates it to treat chemotherapy-induced anaemia, used with care because it can raise the risk of blood clots and, in some cancers, tumour growth. This dossier gathers the 1 product (1 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cytokine receptor on erythroid progenitors signalling through JAK2 and STAT5; agonised by recombinant erythropoiesis-stimulating agents.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Metastatic cancer | host% | Host target: erythropoietin receptor on marrow red-cell precursors. Not a tumour alteration, so no prevalence applies; the drug acts on normal tissue or on symptoms. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Approved |
|---|---|
| Recombinant erythropoietin 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
XM01-22 ISRCTN08063129 | 3 | Positive | Anaemic adults with solid tumours or non-myeloid haematological malignancies receiving nonplatinum chemotherapy: epoetin theta 20,000 IU subcutaneously once weekly versus placebo for 12 weeks | Complete haemoglobin response 72.6% vs 25.3% with placebo (P<0.0001); transfusions after randomisation 13.7% vs 25.3% (P = 0.0277). |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Erythropoietin receptor" OR ABSTRACT:"Erythropoietin receptor" OR TITLE:"EPOR" OR ABSTRACT:"EPOR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Erythropoietin receptor (EPOR), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/epor.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/epor.json. Licence CC BY-NC 4.0.