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ELL (RNA polymerase II elongation factor ELL) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer, Breast cancer, Skin cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilising RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilise the pre-initiation complex and early elongation. Location: Nucleus; Nucleus speckle; Nucleus, Cajal body (UniProt). Locus 19p13.11 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
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Query for this target: (TITLE:"ELL" OR ABSTRACT:"ELL" OR TITLE:"elongation factor for RNA polymerase II" OR ABSTRACT:"elongation factor for RNA polymerase II" OR TITLE:"RNA polymerase II elongation factor ELL" OR ABSTRACT:"RNA polymerase II elongation factor ELL" OR TITLE:"Men" OR ABSTRACT:"Men" OR TITLE:"ELL1" OR ABSTRACT:"ELL1" OR TITLE:"PPP1R68" OR ABSTRACT:"PPP1R68") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELL, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ell.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ell.json. Licence CC BY-NC 4.0.