Loading
ELF3 (ETS-related transcription factor Elf-3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Colorectal cancer and Biliary tract cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. Location: Cytoplasm; Nucleus (UniProt). Locus 1q32.1 (HGNC).
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Gallbladder cancer | 9% | Frameshift and truncating mutation | Mutation in 21 of 244 samples, 8.6%, in cBioPortal gbc_mskcc_2022; a significantly altered gene across 260 biliary cancers (Nakamura 2015) and across 167 gallbladder cancers, where most alterations were frameshifts yielding T-cell-activating neoantigens (Pandey 2020). | cBioPortal (TCGA) |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ELF3" OR ABSTRACT:"ELF3" OR TITLE:"E74 like ETS transcription factor 3" OR ABSTRACT:"E74 like ETS transcription factor 3" OR TITLE:"ETS-related transcription factor Elf-3" OR ABSTRACT:"ETS-related transcription factor Elf-3" OR TITLE:"EPR-1" OR ABSTRACT:"EPR-1" OR TITLE:"ESE-1" OR ABSTRACT:"ESE-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELF3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/elf3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/elf3.json. Licence CC BY-NC 4.0.