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EFTUD2 (116 kDa U5 small nuclear ribonucleoprotein component) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Multiple myeloma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Location: Nucleus (UniProt). Locus 17q21.31 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"EFTUD2" OR ABSTRACT:"EFTUD2" OR TITLE:"elongation factor Tu GTP binding domain containing 2" OR ABSTRACT:"elongation factor Tu GTP binding domain containing 2" OR TITLE:"116 kDa U5 small nuclear ribonucleoprotein component" OR ABSTRACT:"116 kDa U5 small nuclear ribonucleoprotein component" OR TITLE:"U5-116KD" OR ABSTRACT:"U5-116KD" OR TITLE:"Snrp116" OR ABSTRACT:"Snrp116" OR TITLE:"Snu114" OR ABSTRACT:"Snu114") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EFTUD2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/eftud2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/eftud2.json. Licence CC BY-NC 4.0.