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The dopamine D2 receptor is how cabergoline and bromocriptine shrink prolactin-secreting pituitary tumours without surgery, and it is the target of the antiemetics metoclopramide and prochlorperazine used during chemotherapy. This dossier gathers the 2 products (2 approved), 3 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
A Gi-coupled G-protein-coupled receptor that lowers cyclic AMP; in the pituitary it suppresses prolactin gene expression and lactotroph proliferation.
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Metastatic cancer | host% | Host target: dopamine receptor; also the target in prolactin-secreting pituitary tumours. Not a tumour alteration, so no prevalence applies; the drug acts on normal tissue or on symptoms. |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
| Modality | Approved |
|---|---|
| Small molecule 2 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 3 | Completed | Dopamine Agonist Cabergoline in Residual Clinically Nonfunctioning Pituitary Adenoma After Transphenoidal Surgery: A Single Center, Open Label and Randomized Clinical Trial | - | ||
| 3 | Recruiting | Safety and Potency of a High Cabergoline Dosage in Microprolactinomas | - | ||
| 3 | Completed | Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"Dopamine D2 receptor" OR ABSTRACT:"Dopamine D2 receptor" OR TITLE:"DRD2" OR ABSTRACT:"DRD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Dopamine D2 receptor, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/drd2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/drd2.json. Licence CC BY-NC 4.0.